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Cdk5i peptide

Chemical Structure : Cdk5i peptide

CAS No.: 2298317-00-5

Cdk5i peptide (Cdk5/p25 inhibitor peptide ARAFGIPVRCYS)

Catalog No.: PC-20494Not For Human Use, Lab Use Only.

Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone.
    Cdk5i peptide ameliorates neurodegenerative phenotypes in cell and mouse models of Cdk5 hyperactivity.

    Physicochemical Properties

    M.Wt 1339.58
    Formula C60H94N18O15S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    Sequence: Ala-Arg-Ala-Phe-Gly-Ile-Pro-Val-Arg-Cys-Tyr-Ser

    References

    1. Ping-Chieh Pao, et al. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2217864120.

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