Cdk5i peptide | Cdk5/p25 inhibitor | Probechem Biochemicals

Chemical Structure : Cdk5i peptide

Cdk5i peptide (Cdk5/p25 inhibitor peptide ARAFGIPVRCYS)

Catalog No.: PC-20494Not For Human Use, Lab Use Only.

Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone.

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Biological Activity

Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone.
Cdk5i peptide ameliorates neurodegenerative phenotypes in cell and mouse models of Cdk5 hyperactivity.

Physicochemical Properties

M.Wt	1339.58
Formula	C60H94N18O15S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Sequence: Ala-Arg-Ala-Phe-Gly-Ile-Pro-Val-Arg-Cys-Tyr-Ser

References

1. Ping-Chieh Pao, et al. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2217864120.

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Cdk5i peptide (Cdk5/p25 inhibitor peptide ARAFGIPVRCYS)

Biological Activity

Physicochemical Properties

References

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