| Cat. No. |
Product Name |
Information |
| PC-60961 |
YKL-1-116
CDK7 inhibitor
|
YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs. |
| PC-60894 |
Cortistatin A
CDK8/19 inhibitor
|
Cortistatin A is a potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19. |
| PC-60893 |
BRD6989
CDK8 inhibitor
|
BRD6989 is a potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex. |
| PC-60582 |
(R)-DRF053 dihydrochloride
CK1/CDK inhibitor
|
(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively. |
| PC-60539 |
BAY-958
CDK9 inhibitor
|
BAY-958 (BAY958, LDC526) is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1. |
| PC-60537 |
Atuveciclib
CDK9 inhibitor
|
Atuveciclib (BAY-1143572) is a potent, highly selective, orally bioavailable CDK9/P-TEFb inhibitor with IC50 of 6 nM for CDK9/CyclinT1. |
| PC-60492 |
CDK12 inhibitor E9 racemate
CDK12 inhibitor
|
CDK12 inhibitor E9 racemate is a clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux. |
| PC-60491 |
CDK12 inhibitor E9 R-isomer
CDK12 inhibitor
|
CDK12 inhibitor E9 R-isomer is a clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux. |
| PC-60490 |
CDK12-IN-E9
CDK12 inhibitor
|
CDK12 inhibitor E9 S-isomer (E9, CDK12-IN-E9) is a clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux. |
| PC-60480 |
Fascaplysin chloride
CDK4 inhibitor
|
Fascaplysin chloride (NSC 622398) is a potent CDK4/cyclin D1 with IC50 of 0.35 uM, 10-fold less potent for significantly for CDK6/cyclin D1 and does not inhibit other Cdks and tyrosine kinases. |
| PC-60479 |
CA224
CDK4 inhibitor
|
CA224 is a non-planar analogue of fascaplysin that selectively inhibits CDK4/cyclin D1 with IC50 of 5.5 uM. |
| PC-60398 |
G1T38 dihydrochloride
CDK4/6 inhibitor
|
Lerociclib (G1T38) dihydrochloride is a potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 2 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
