YKL-1-116 | CDK7 inhibitor | Probechem Biochemicals

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Chemical Structure : YKL-1-116

YKL-1-116 (CDK7 inhibitor)

Catalog No.: PC-60961Not For Human Use, Lab Use Only.

YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs.
YKL-1-116 synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage.
YKL-1-116 is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant).

Physicochemical Properties

M.Wt	606.731
Formula	C34H38N8O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-((3-(4-acrylamidobenzamido)phenyl)amino)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

References

1. Kalan S, et al. Cell Rep. 2017 Oct 10;21(2):467-481.

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