| Cat. No. |
Product Name |
Information |
| PC-21090 |
RGB-286199
CDK inhibitor
|
RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo. |
| PC-21089 |
RGB-286638
CDK inhibitor
|
RGB-286638 is a small-molecule multi-targeted cyclin-dependent kinase (CDK) inhibitor with IC50 of 1-5 nM for cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5. |
| PC-21053 |
HQ461
cyclin K degrader
|
HQ461 is a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation, exhibits potent cytotoxicity to NSCLC cell line A549 with with IC50 of 1.3 uM. |
| PC-20887 |
CDK2 inhibitor 5
CDK2 inhibitor
|
CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1. |
| PC-20872 |
Ribociclib
CDK4/6 inhibitor
|
Ribociclib (LEE-011, LEE011) is a potent, highly selective, orally bioavailable CDK4/6 inhibitor with IC50 of 10/39 nM, respectively. |
| PC-20691 |
NCGC00131308
IQGAP1-Cdc42 inhibitor
|
NCGC00131308 is a small molecule inhibitor that effectively disrupts IQGAP1-Cdc42 interaction in breast cancer cells, shows EC50 of 4.47 uM in biochemical HTRF assays. |
| PC-20589 |
Abemaciclib
CDK4/6 inhibitor
|
Abemaciclib (LY2835219) is a potent, selective and competitive ATP CDK4/6 inhibitor with Ki values of 0.6 and 2.4 nM for CDK4/cyclin D1 and CDK6/cyclin D1, respectively. |
| PC-20494 |
Cdk5i peptide
Cdk5/p25 inhibitor
|
Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone. |
| PC-20315 |
LGR6768
CDK7 inhibitor
|
LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs. |
| PC-20284 |
QR-6401
CDK2 inhibitor
|
QR-6401 (QR6401) is a highly potent, selective, oral macrocyclic CDK2 inhibitor. |
| PC-20283 |
PF-07104091
CDK2 inhibitor
|
PF-07104091 (PF 07104091) is a highly potent CDK2-selective inhibitor with potential for the treatment of cyclinE-amplified cancers. |
| PC-49787 |
BMS-357075
pan CDK inhibitor
|
BMS-357075 is a potent pan inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 18, 3 and 26 nM for CDK1, CDK2, and CDK4, respectively, also inhibits CDK20 with Kd of 56 nM. |
