Chemical Structure : Trilaciclib hydrochloride
Catalog No.: PC-60396Not For Human Use, Lab Use Only.
A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 4 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively.
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A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 4 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively; displays >30-fold selectivity for CDK4/cyclin D1 over CDK2/cyclin A, CDK2/cyclin E, CDK5/p25, CDK5/p35, and CDK7/cyclin H/Mat1, 50-fold over CDK9/cyclin T; reversibly pauses the cell cycle in the G1 phase in CDK4/6-dependent cell lines, protects CDK4/6-dependent cells from chemotherapy-induced damage in vitro; induces a reversible cell-cycle arrest in murine and canine HSPCs; attenuates chemotherapy-induced myelosuppression in vivo.
Breast Cancer
Phase 2 Clinical
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Appearance | Solid | |
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10 mM in DMSO |
1. Bisi JE, et al. Mol Cancer Ther. 2016 May;15(5):783-93.
2. He S, et al. Sci Transl Med. 2017 Apr 26;9(387). pii: eaal3986.
3. Stice JP, et al. Mol Cancer Res. 2017 Jun;15(6):660-669.
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