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Chemical Structure : NU-6027
CAS No.: 220036-08-8
Catalog No.: PC-70116Not For Human Use, Lab Use Only.
NU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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NU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively.
NU-6027 (NU6027) inhibits human tumor cells with a mean GI50 of 10 ±6 uM.
NU-6027 (NU6027) also inhibits cellular ATR (IC50=6.7 uM) and RAD51 focus formation, increases the cytotoxicity of the major classes of DNA-damaging anticancer cytotoxic therapy.
| M.Wt | 251.3 | |
| Formula | C11H17N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine |
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1. Arris CE, et al. J Med Chem. 2000 Jul 27;43(15):2797-804.
2. Peasland A, et al. Br J Cancer. 2011 Jul 26;105(3):372-81.
3. Boschi D, et al. Eur J Med Chem. 2013 Oct;68:333-8.
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