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NU-6027

Chemical Structure : NU-6027

CAS No.: 220036-08-8

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NU-6027 (NU6027;NU 6027)

Catalog No.: PC-70116Not For Human Use, Lab Use Only.

NU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively.

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10 mg $108 In stock
25 mg $188 In stock
50 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively.
NU-6027 (NU6027) inhibits human tumor cells with a mean GI50 of 10 ±6 uM.
NU-6027 (NU6027) also inhibits cellular ATR (IC50=6.7 uM) and RAD51 focus formation, increases the cytotoxicity of the major classes of DNA-damaging anticancer cytotoxic therapy.

Physicochemical Properties

M.Wt 251.3
Formula C11H17N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine

References

1. Arris CE, et al. J Med Chem. 2000 Jul 27;43(15):2797-804.

2. Peasland A, et al. Br J Cancer. 2011 Jul 26;105(3):372-81.

3. Boschi D, et al. Eur J Med Chem. 2013 Oct;68:333-8.

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