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Chemical Structure : NU6102
CAS No.: 444722-95-6
Catalog No.: PC-70115Not For Human Use, Lab Use Only.
NU6102 is a potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NU6102 is a potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively.
NU6102 exhibits synergistic growth inhibition, and enhanced cytotoxicity in HT29 cells in vitro and HT29 tumour growth inhibition in vivo combined with Pictilisib.
NU6102 induces G2 arrest, inhibition of Rb phosphorylation and cytotoxicity in SKUT-1B cells (LC50=2.6 uM, for a 24h exposure).
| M.Wt | 402.5 | |
| Formula | C18H22N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((3R,6S,9S,12R)-6-ethyl-9-(3-guanidinopropyl)-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclohexadecan-12-yl)isobutyramide |
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1. Hardcastle IR, et al. J Med Chem. 2004 Jul 15;47(15):3710-22.
2. Beale G, et al. Br J Cancer. 2016 Sep 6;115(6):682-90.
3. Thomas HD, et al. Eur J Cancer. 2011 Sep;47(13):2052-9.
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