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Chemical Structure : MSC2530818
CAS No.: 1883423-59-3
Catalog No.: PC-60298Not For Human Use, Lab Use Only.
MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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MSC2530818 (MSC 2530818, MSC-2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
MSC2530818 binds to CDK8 and CDK19 with similar affinity (4 nM), and displays good selectivity profile in a 264 kinase panel with exception of GSK3α (IC50=691 nM).
MSC2530818 potently inhibits of phospho-STAT1 S727 in SW620 cells (IC50=8 nM), shows potent inhibition of WNT-dependent transcription in human cancer cell lines.
MSC2530818 demonstrates tumor growth inhibition in an APC mutant SW620 human colorectal carcinoma xenograft model.
| M.Wt | 340.811 | |
| Formula | C18H17ClN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone |
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1. Czodrowski P, et al. J Med Chem. 2016 Oct 27;59(20):9337-9349.
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