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Chemical Structure : NVP-2
CAS No.: 1263373-43-8
Catalog No.: PC-60329Not For Human Use, Lab Use Only.
NVP-2 is a potent, selective, ATP-competitive CDK9 inhibitor with IC50 of <0.514 nM (CDK9/CyclinT).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $478 | In stock | |
| 100 mg | Get quote |
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NVP-2 is a potent, selective, ATP-competitive CDK9 inhibitor with IC50 of <0.514 nM (CDK9/CyclinT).
NVP-2 displays excellent kinome selectivity against a panel of 468 kinases, including CDK7 (IC50>10 uM) and CDK13.
NVP-2 inhibits proliferation of MOLT4 cells with IC50 of 9 nM, inhibits phosphorylation of RNA Pol II CTD residues serine 2, 5 and 7, induces significant reductions in the mRNA levels of MYB and RUNX1 in MOLT4 cells.
| M.Wt | 513.083 | |
| Formula | C27H37ClN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(((2'-chloro-5'-(((1R,4r)-4-(((R)-1-methoxypropan-2-yl)amino)cyclohexyl)amino)-[2,3'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile |
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1. Olson CM, et al. Nat Chem Biol. 2017 Dec 18. doi: 10.1038/nchembio.2538.
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