| Cat. No. |
Product Name |
Information |
| PC-24198 |
Zeltociclib
CDK7 inhibitor
|
Zeltociclib is a potent, specific CDK7 inhibitor. |
| PC-24041 |
F059-1017
CDK8 inhibitor
|
F059-1017 is a potent, selective CDK8 inhibitor with IC50 of 558.1 nM, reduces phosphorylation and expression of signaling mediators associated with inflammation. |
| PC-23981 |
Arcyriaflavin A
CDK4 inhibitor
|
Arcyriaflavin A is a potent inhibitor of the cyclin D1/CDK4 complex with IC50 of 140 nM, also inhibits CaMKII with IC50 of 25 nM, suppresses tumor growth, migration, and invasion of metastatic melanoma cells. |
| PC-23770 |
E966-0530-45418
CDK8 inhibitor
|
E966-0530-45418 is a potent, selective inhibitor of CDK8 with IC50 of 129 nM, shows slightly weaker activity against CDK19 and does not inhibit other CDKs. |
| PC-23151 |
CDK-TCIP2
|
CDK-TCIP2 is a bivalent molecule linking CDK9 inhibitor SNS-032 to BCL6 ligand BI3812, activates BCL6-regulated transcription, potently and specifically kills BCL6-overexpressing cells with EC50 of 0.9 nM for SUDHL5 cells. |
| PC-23150 |
CDK-TCIP1
3008612-35-6
|
CDK-TCIP1 is a bivalent molecule linking CDK9 inhibitor SNS-032 to BCL6 ligand BI3812, potently and specifically kills BCL6-overexpressing cells with EC50 of 7.7 nM for SUDHL5 cells. |
| PC-23046 |
Myrtleciclib
CDK4/6/9 inhibitor
|
Myrtleciclib (VS2 370) is a potent, selective CDK4/6/9 inhibitor. |
| PC-23020 |
YK-2168 hydrochloride
CDK9 inhibitor
|
YK-2168 hydrochloride is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2. |
| PC-22926 |
TMX-3013
CDK inhibitor
|
TMX-3013 is a potent, multi-CDK inhibitor with IC50 of 0.9/<0.5/0.5/24.5/15.6 nM for CDK1/2/5/4/6 respectively. |
| PC-22841 |
CDKL3 inhibitor HZ1
CDKL3 inhibitor
|
CDKL3 inhibitor HZ1 (C3I-22) is a first-in-class, specific inhibitor of CDKL3 (Cyclin-dependent kinase like 3) inhibitor with Kd of 5.16 uM, blocks CDKL3 mediated cell cycle progression both in vitro and in vivo |
| PC-22396 |
CDKL2 inhibitor 9
CDKL2 inhibitor
|
CDKL2 inhibitor 9 is a selective cyclin-dependent kinase-like 2 (CDKL2, KKIAMRE, P56) chemical probe inhibitor with enzyme IC50 of 230 nM in radiometric enzymatic assays. |
| PC-22032 |
KY-273
CDK8/19 inhibitor
|
KY-273 (KY273) is a potent, specific CDK8/19 inhibitor with IC50 of 29.1 and 44.7 nM respectively, promotes osteoblast differentiation and has cortical-bone-selective osteogenic effects. |
