Chemical Structure : CID-078
CAS No.:
3064485-16-8
CID-078
(CID078)
Catalog No.: PC-27526Not For Human Use, Lab Use Only.
CID-078 is a highly potent, first-in-class, oral macrocycle cyclin A/B-RxL inhibitor with IC50 of <0.02 uM for both cyclin A and cyclin B in FP assays, Kd of 1.1 nM and 0.83 nM for cyclin A and cyclin B respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CID-078 is a highly potent, first-in-class, oral macrocycle cyclin A/B-RxL inhibitor with IC50 of <0.02 uM for both cyclin A and cyclin B in FP assays, Kd of 1.1 nM and 0.83 nM for cyclin A and cyclin B respectively.
CID-078 drives replication stress and mitotic catastrophe, leading to tumor cell death.
CID-078 (50-100 mg/kg PO BID) inhibits tumor growth inhibition in a SCLC CDX model. CID-078 demonstrates greater activity in an Rb-deficient vs Rb-proficient lung PDX model.
Physicochemical Properties
|
M.Wt
|
985.51
|
|
Formula
|
C47H63ClF6N8O6
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
L-Phenylalanine, (4R)-1-[[3,3-difluoro-1-(trifluoromethyl)cyclobutyl]carbonyl]-4-fluoro-L-prolyl-(2S)-2-cyclopropylglycyl-2,9-bis(methylamino)nonanoyl-L-leucyl-5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-N-methyl-, (5→3)-lactam
|
References
1. Patent WO2024243010 A1 2024-11-28.
Contact Us
sales@probechem.com
