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Chemical Structure : Dinaciclib
CAS No.: 779353-01-4
Catalog No.: PC-42616Not For Human Use, Lab Use Only.
Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.
Dinaciclib (SCH 727965) completely suppresses Rb phosphorylation and inhibits bromodeoxyuridine incorporation in >100 tumor cell lines.
Dinaciclib (SCH 727965) exhibits superior activity with an improved therapeutic index compared with flavopiridol.
| M.Wt | 396.486 | |
| Formula | C21H28N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 56 mg/mL |
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| Chemical Name/SMILES |
2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)- |
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1. Parry D, et al. Mol Cancer Ther. 2010 Aug;9(8):2344-53.
2. Paruch K, et al. ACS Med Chem Lett. 2010 May 17;1(5):204-8.
3. Feldmann G, et al. Cancer Biol Ther. 2011 Oct 1;12(7):598-609.
4. Johnson AJ, et al. Leukemia. 2012 Dec;26(12):2554-7.
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