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Dinaciclib

Chemical Structure : Dinaciclib

CAS No.: 779353-01-4

Dinaciclib (SCH727965, SCH-727965)

Catalog No.: PC-42616Not For Human Use, Lab Use Only.

Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.
Dinaciclib (SCH 727965) completely suppresses Rb phosphorylation and inhibits bromodeoxyuridine incorporation in >100 tumor cell lines.
Dinaciclib (SCH 727965) exhibits superior activity with an improved therapeutic index compared with flavopiridol.

Physicochemical Properties

M.Wt 396.486
Formula C21H28N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 56 mg/mL

Chemical Name/SMILES

2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)-

References

1. Parry D, et al. Mol Cancer Ther. 2010 Aug;9(8):2344-53.

2. Paruch K, et al. ACS Med Chem Lett. 2010 May 17;1(5):204-8.

3. Feldmann G, et al. Cancer Biol Ther. 2011 Oct 1;12(7):598-609.

4. Johnson AJ, et al. Leukemia. 2012 Dec;26(12):2554-7.

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