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Chemical Structure : AZD-5438
CAS No.: 602306-29-6
Catalog No.: PC-42060Not For Human Use, Lab Use Only.
AZD-5438 (AZD5438) potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $18 | In stock | |
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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AZD-5438 (AZD5438) potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively.
AZD-5438 also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro, displays 75-fold less active against cyclin D-Cdk4.
AZD-5438 shows significant antiproliferative activity in human tumor cell lines (IC50 range: 0.2-1.7 uM), inhibits the phosphorylation of Cdk substrates pRb, nucleolin, PP1A, and RNA polymerase II COOH-terminal domain and blocks cell cycle.
AZD-5438 inhibits the human tumor xenograft growth in vivo.
AZD-5438 also inhibits PASTA kinase in L. monocytogenes (PrkA) and L. monocytogenes growth in a β-lactam-synergism-dependent manner.
| M.Wt | 371.4566 | |
| Formula | C18H21N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyrimidinamine, 4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]- |
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1. Byth KF, et al. Mol Cancer Ther. 2009 Jul;8(7):1856-66.
2. Boss DS, et al. Ann Oncol. 2010 Apr;21(4):884-94.
3. Pensinger DA, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4486-94.
4. Raghavan P, et al. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14.
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