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Chemical Structure : JNJ-7706621
CAS No.: 443797-96-4
Catalog No.: PC-42527Not For Human Use, Lab Use Only.
JNJ-7706621 is a potent, dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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JNJ-7706621 is a potent, dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively.
JNJ-7706621 also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM), and no activity for Plk1 or Wee1.
JNJ-7706621 arrests the cell cycle at the G2-M phase.
JNJ-7706621 shows significant antitumor activity in tumor xenograft model.
| M.Wt | 394.356 | |
| Formula | C15H12F2N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]- |
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1. Emanuel S, et al. Cancer Res. 2005 Oct 1;65(19):9038-46.
2. Huang S, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41.
3. Seamon JA, et al. Mol Cancer Ther. 2006 Oct;5(10):2459-67.
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