Cucurbitacin E | Cyclin B1 inhibitor | Probechem Biochemicals

Chemical Structure : Cucurbitacin E

CAS No.: 18444-66-1

Cucurbitacin E (α-Elaterin, α-Elaterine)

Catalog No.: PC-27637Not For Human Use, Lab Use Only.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$198	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Cucurbitacin E (α-elaterin) is a strong antifeedant natural compound with the ability to disrupt cell actin and cell adhesion, induces CRC G2/M phase arrest via cell division cycle gene 2 (CDC2) downregulation and dissociation of the cyclin B1/CDC2 complex.
Cucurbitacin E inhibits cell survival/proliferation of primary CRC cell lines.
Cucurbitacin E-induced cell cycle arrest in CRC cells occurs via a mechanism other than the accumulation of intracellular ROS.
Cucurbitacin E induces accumulation of G2/M phase in CRC cells.
Cucurbitacin E induces G2/M arrest in CRC cells via integration of GADD45 γ with CDC2.
Cucurbitacin E also induces PANoptosis in adrenocortical carcinoma cells in a ZBP1-dependent manner.

Physicochemical Properties

M.Wt	556.70
Formula	C32H44O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,E)-6-((8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-4,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

References

1. Hsu YC, et al. Cell Death Dis. 2014 Apr 24;5(4):e1198.

2. Murtaza M, et al. PLoS One. 2017 Jun 9;12(6):e0178910.

3. Hung CM, et al. Sci Rep. 2014 Sep 23;4:6454.

Cucurbitacin E (α-Elaterin, α-Elaterine)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.