| Cat. No. |
Product Name |
Information |
| PC-72776 |
Senexin C
CDK8/19 inhibitor
|
Senexin C is a novel potent, selective and orally bioavailable CDK8/19 inhibitor with Kd of 1.4 and 2.9 nM for CDK8/CycC and CDK19/CycC, respectively. |
| PC-72755 |
AS-0141
CDC7 inhibitor
|
Monzosertib (AS 0141) is a potent, selective, orally bioavailable CDC7 inhibitor with IC50 of 2.4 nM. |
| PC-72673 |
BRD6688
HDAC2 inhibitor
|
BRD6688 is a potent, kinetically selective HDAC2 inhibitor with IC50 of 21/100 nM for HDAC1/2, >115-fold selectivity versus HDAC3. |
| PC-72642 |
SY-1365
CDK7 inhibitor
|
SY-1365 (Mevociclib, SY1365) is a potent, selective, covalent CDK7 inhibitor with Ki of 17.4 nM. |
| PC-72637 |
CDDD2-94
CDK4 inhibitor
|
CDDD2-94 is a highly potent and selective CDK4 inhibitor with Ki of 2 nM, 140-fold more selective for CDK4 over CDK6 (Ki=279 nM). |
| PC-72622 |
PF-06842874
CDK4/6 inhibitor
|
PF-06842874 is a potent, selective CDK4/6 inhibitor. |
| PC-72467 |
LY3405105
CDK7 inhibitor
|
LY3405105 (LY-3405105) is a potent, selective, orally active CDK7 inhibitor with an IC50 of 92.8 nM, shows potential antineoplastic activity. |
| PC-72466 |
SY-5102
CDK7 inhibitor
|
SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H). |
| PC-72216 |
MFH290
CDK12/13 inhibitor
|
MFH290 (MFH-290) is a potent, highly selective, covalent inhibitor of CDK12/13 with IC50 of 25/49 nM. |
| PC-38299 |
(R)-CR8
CDK inhibitor
|
(R)-CR8 is a potent CDK1/2/5/7/9 inhibitor, inhibits CDK1/cyclin B (IC50, 90 nM), CDK2/cyclin A (72 nM), CDK2/cyclin E (41 nM), CDK5/p25 ( 110 nM), CDK7/cyclin H (1.1 uM), CDK9/cyclin T (0.18 uM) and CK1δ/ε (0.4 uM). |
| PC-38278 |
KB-0742
CDK9 inhibitor
|
KB-0742 (KB0742) is a potent, orally bioavailable, selective CDK9 inhibitor with IC50 of 6 nM (CDK9/cyclin T1 inhibition). |
| PC-38149 |
A-1592668
CDK9 inhibitor
|
A-1592668 (A 1592668) is a novel potent, CDK9-selective inhibitor with IC50 of 1.2 nM, >1000 fold selectivity over CDK1/2/7/8. |
