BMS-357075 | pan CDK inhibitor | Probechem Biochemicals

Chemical Structure : BMS-357075

BMS-357075 (BMS357075)

Catalog No.: PC-49787Not For Human Use, Lab Use Only.

BMS-357075 is a potent pan inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 18, 3 and 26 nM for CDK1, CDK2, and CDK4, respectively, also inhibits CDK20 with Kd of 56 nM.

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Biological Activity

BMS-357075 is a potent pan inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 18, 3 and 26 nM for CDK1, CDK2, and CDK4, respectively, also inhibits CDK20 with Kd of 56 nM.

Physicochemical Properties

M.Wt	461.64
Formula	C22H31N5O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Propanol, 3-[[[6-[[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]amino]-3-pyridinyl]methyl]amino]-2,2-dimethyl-

References

1. Seyedeh Roya Alizadeh, et al. Med Chem Res. 2021;30(4):771-806.

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BMS-357075 (BMS357075)

Biological Activity

Physicochemical Properties

References

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