Chemical Structure : Atirmociclib
CAS No.: 2380321-51-5
Catalog No.: PC-49575Not For Human Use, Lab Use Only.
Atirmociclib (PF-07220060) is a potent and selective, orally active CDK4 inhibitor with Ki of 0.6 nM (CDK4/Cyclin D1), significant sparing of CDK6 (Ki=13.9 nM CDK6/Cyclin D3).
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Atirmociclib (PF-07220060) is a potent and selective, orally active CDK4 inhibitor with Ki of 0.6 nM (CDK4/Cyclin D1), significant sparing of CDK6 (Ki=13.9 nM CDK6/Cyclin D3).
| M.Wt | 462.95 | |
| Formula | C23H28ClFN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(3S,4R)-4-((5-chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)amino)tetrahydro-2H-pyran-3-ol |
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1. Patent WO2019207463A1.
2. Lars Anders, et al. Cancer Res (2024) 84 (7_Supplement): ND12.
3. Palmer CL, et al. Cancer Cell. 2025 Mar 10;43(3):464-481.e14.

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