Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : QR-6401
Catalog No.: PC-20284Not For Human Use, Lab Use Only.
QR-6401 (QR6401) is a highly potent, selective, oral macrocyclic CDK2 inhibitor.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
QR-6401 (QR6401) is a highly potent, selective, oral macrocyclic CDK2 inhibitor with IC50 of 0.37 nM (CDK2/Cyclin E1).
QR-6401 exhibits good selectivity against other closely related kinases, such as CDK1, CDK4, CDK6, CDK9 and GSK3β.
QR-6401 demonstrates good intrinsic metabolic stability and acceptable plasma protein binding in different species.
QR-6401 ( twice daily through oral gavage at 50 mg/kg for 28 days) caused significant tumor growth inhibition (TGI% = 78%) in OVCAR3 ovarian cancer xenograft model, produced robust suppression of Rb phosphorylation
| M.Wt | 369.43 | |
| Formula | C19H23N5O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Yang Yu, et al. ACS Med Chem Lett. 2023 Feb 8;14(3):297-304.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
