Catalog No.: PC-49792Not For Human Use, Lab Use Only.
CDKL5/GSK3 inhibitor 2 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively.
SGC-CDKL5/GSK3-1 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively.
SGC-CDKL5/GSK3-1 displays exquisitely selectivity against CDKL family (CDKL1/2/3) and the Eurofins DiscoverX scanMAX panel including 403 wild-type (WT) human as well as several mutant and non-human kinases.
SGC-CDKL5/GSK3-1 potently inhibits CDKL5 kinase activity and downstream signaling, demonstrates canonical ATP-competitive binding to CDKL5.
SGC-CDKL5/GSK3-1 (5 nM) inhibits phosphorylation of EB2 and phospho-β-catenin in DIV15-16 cortical primary rat neurons.
SGC-CDKL5/GSK3-1 promotes survival of motor neurons in response to ER stress, which is a hallmark of neurodegenerative diseases like ALS.
