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Chemical Structure : EF-4-177
Catalog No.: PC-49698Not For Human Use, Lab Use Only.
EF-4-177 is a potent, selective, allosteric and orally active CDK2 inhibitor with ITC KD of 7.4 nM.
EF-4-177 binds CDK2 in a manner that is negatively cooperative with cyclin binding.
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EF-4-177 is a potent, selective, allosteric and orally active CDK2 inhibitor with ITC KD of 7.4 nM.
EF-4-177 binds CDK2 in a manner that is negatively cooperative with cyclin binding.
EF-4-177 is selective for CDK2 over structurally similar CDK1, showing the promise of targeting the allosteric pocket to achieve selectivity.
EF-4-177 significantly decreased sperm count in CD-1 mice after the 28 day exposure.
| M.Wt | 431.38 | |
| Formula | C18H14F5N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Erik B Faber, et al. J Med Chem. 2023 Jan 26. doi: 10.1021/acs.jmedchem.2c01731.
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