| Cat. No. |
Product Name |
Information |
| PC-20283 |
PF-07104091
CDK2 inhibitor
|
Tagtociclib (PF-07104091) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers. |
| PC-20219 |
CDK8 inhibitor 32
CDK8 inhibitor
|
CDK8 inhibitor 32 is a potent selective CDK8 inhibitor with IC50 of 1.5 nM, reduces phosphorylation of the known CDK8 substrate STAT1 in a manner identical to a CDK8 knockout clone. |
| PC-49792 |
SGC-CDKL5/GSK3-1
CDKL5/GSK3 inhibitor
|
CDKL5/GSK3 inhibitor 2 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively. |
| PC-49789 |
RGB-286147
CDK inhibitor
|
RGB-286147 (RGB 286147) is a proteome-wide CDK/CRK-specific kinase inhibitor with IC50 of 48 and 15 nM for CDK1/CycB and CDK2/CycE, respectively. |
| PC-49787 |
BMS-357075
pan CDK inhibitor
|
BMS-357075 is a potent pan inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 18, 3 and 26 nM for CDK1, CDK2, and CDK4, respectively, also inhibits CDK20 with Kd of 56 nM. |
| PC-49785 |
ISM042-2-048
CDK20 inhibitor
|
ISM042-2-048 is a potent, selective inhibitor of cyclin-dependent kinase 20 (CDK20, cell cycle-related kinase/CCRK) with IC50 of 33.4 nM (CDK20/CycT1), Kd value of 566 nM. |
| PC-49575 |
Atirmociclib
CDK4 inhibitor
|
Atirmociclib (PF-07220060) is a potent and selective, orally active CDK4 inhibitor with Ki of 0.6 nM (CDK4/Cyclin D1), significant sparing of CDK6 (Ki=13.9 nM CDK6/Cyclin D3). |
| PC-49485 |
KB-0742 dihydrochloride
CDK9 inhibitor
|
KB-0742 (KB0742) is a potent, orally bioavailable, selective CDK9 inhibitor with IC50 of 6 nM (CDK9/cyclin T1 inhibition). |
| PC-49444 |
MK256
CDK8/19 inhibitor
|
MK256 (MK-256) is a potent, selective CDK8 inhibitor with IC50 of 2.5 nM and 3.3 nM against CDK8/cyclin C and CDK19/cyclin C, respectively. |
| PC-49295 |
BML-259
CDK5 inhibitor
|
BML-259 (BML259) is a potent, specific Cdk5/p25 and Cdk2 inhibitor with IC50 of 64 and 98 nM, respectively. |
| PC-49260 |
ZSQ836
CDK12/13 inhibitor
|
ZSQ836 (ZSQ 836) is a potent, selective and orally bioavailable CDK12/CDK13 covalent inhibitor with IC50 of 32 nM (CDK12), covalently interacts with Cys1039 of CDK12. |
| PC-49204 |
SNX631
CDK8/19 inhibitor
|
SNX631 (SNX-631) is a potent, selective inhibitor of CDK8/19 Mediator kinase with IC50 of 10.3 nM in the NF κB-dependent cell-based assays. |
