| Cat. No. |
Product Name |
Information |
| PC-73186 |
NCT02
CCNK-CDK12 degarder
|
NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12. |
| PC-73102 |
SR-4835
CDK12/13 inhibitor
|
SR-4835 (SR4835) is a potent, highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 98 and 4.9 nM, respectively. |
| PC-72894 |
GFB-12811
CDK5 inhibitor
|
GFB-12811 (GFB12811) is a potent, highly selective CDK5 inhibitor with IC50 of 2.3 nM. |
| PC-72777 |
SY-5609
CDK7 inhibitor
|
SY-5609 (SY5609) is a highly potent, selective, noncovalent and orally available inhibitor of CDK7 with Kd of 0.07 nM in SPR assays (binding to CDK7/Cyclin H). |
| PC-72776 |
Senexin C
CDK8/19 inhibitor
|
Senexin C is a novel potent, selective and orally bioavailable CDK8/19 inhibitor with Kd of 1.4 and 2.9 nM for CDK8/CycC and CDK19/CycC, respectively. |
| PC-72755 |
AS-0141
CDC7 inhibitor
|
Monzosertib (AS 0141) is a potent, selective, orally bioavailable CDC7 inhibitor with IC50 of 2.4 nM. |
| PC-72673 |
BRD6688
HDAC2 inhibitor
|
BRD6688 is a potent, kinetically selective HDAC2 inhibitor with IC50 of 21/100 nM for HDAC1/2, >115-fold selectivity versus HDAC3. |
| PC-72642 |
SY-1365
CDK7 inhibitor
|
SY-1365 (Mevociclib, SY1365) is a potent, selective, covalent CDK7 inhibitor with Ki of 17.4 nM. |
| PC-72637 |
CDDD2-94
CDK4 inhibitor
|
CDDD2-94 is a highly potent and selective CDK4 inhibitor with Ki of 2 nM, 140-fold more selective for CDK4 over CDK6 (Ki=279 nM). |
| PC-72622 |
PF-06842874
CDK4/6 inhibitor
|
PF-06842874 is a potent, selective CDK4/6 inhibitor. |
| PC-72467 |
LY3405105
CDK7 inhibitor
|
LY3405105 (LY-3405105) is a potent, selective, orally active CDK7 inhibitor with an IC50 of 92.8 nM, shows potential antineoplastic activity. |
| PC-72466 |
SY-5102
CDK7 inhibitor
|
SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H). |
