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Cat. No. Product Name Information
PC-20316

LDC4297

CDK7 inhibitor

LDC4297 (LDC044297) is a potent, highly specific CDK7 inhibitor with IC50 of 7.4 nM in ATP competition assays (3.5 mM ATP), weakly inhibits CDK2 (IC50>2 uM).
PC-20315

LGR6768

CDK7 inhibitor

LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs.
PC-20284

QR-6401

CDK2 inhibitor

QR-6401 (QR6401) is a highly potent, selective, oral macrocyclic CDK2 inhibitor.
PC-20283

PF-07104091

CDK2 inhibitor

Tegtociclib (PF-07104091, Tagtociclib) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers.
PC-20219

CDK8 inhibitor 32

CDK8 inhibitor

CDK8 inhibitor 32 is a potent selective CDK8 inhibitor with IC50 of 1.5 nM, reduces phosphorylation of the known CDK8 substrate STAT1 in a manner identical to a CDK8 knockout clone.
PC-49792

SGC-CDKL5/GSK3-1

CDKL5/GSK3 inhibitor

CDKL5/GSK3 inhibitor 2 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively.
PC-49789

RGB-286147

CDK inhibitor

RGB-286147 (RGB 286147) is a proteome-wide CDK/CRK-specific kinase inhibitor with IC50 of 48 and 15 nM for CDK1/CycB and CDK2/CycE, respectively.
PC-49787

BMS-357075

pan CDK inhibitor

BMS-357075 is a potent pan inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 18, 3 and 26 nM for CDK1, CDK2, and CDK4, respectively, also inhibits CDK20 with Kd of 56 nM.
PC-49785

ISM042-2-048

CDK20 inhibitor

ISM042-2-048 is a potent, selective inhibitor of cyclin-dependent kinase 20 (CDK20, cell cycle-related kinase/CCRK) with IC50 of 33.4 nM (CDK20/CycT1), Kd value of 566 nM.
PC-49575

Atirmociclib

CDK4 inhibitor

Atirmociclib (PF-07220060) is a potent and selective, orally active CDK4 inhibitor with Ki of 0.6 nM (CDK4/Cyclin D1), significant sparing of CDK6 (Ki=13.9 nM CDK6/Cyclin D3).
PC-49485

KB-0742 dihydrochloride

CDK9 inhibitor

Istisociclib dihydrochloride (KB-0742) is a potent, orally bioavailable, selective CDK9 inhibitor with IC50 of 6 nM (CDK9/cyclin T1 inhibition).
PC-49444

MK256

CDK8/19 inhibitor

MK256 (MK-256) is a potent, selective CDK8 inhibitor with IC50 of 2.5 nM and 3.3 nM against CDK8/cyclin C and CDK19/cyclin C, respectively.

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