| Cat. No. |
Product Name |
Information |
| PC-49485 |
KB-0742 dihydrochloride
CDK9 inhibitor
|
KB-0742 (KB0742) is a potent, orally bioavailable, selective CDK9 inhibitor with IC50 of 6 nM (CDK9/cyclin T1 inhibition). |
| PC-49444 |
MK256
CDK8/19 inhibitor
|
MK256 (MK-256) is a potent, selective CDK8 inhibitor with IC50 of 2.5 nM and 3.3 nM against CDK8/cyclin C and CDK19/cyclin C, respectively. |
| PC-49295 |
BML-259
CDK5 inhibitor
|
BML-259 (BML259) is a potent, specific Cdk5/p25 and Cdk2 inhibitor with IC50 of 64 and 98 nM, respectively. |
| PC-49260 |
ZSQ836
CDK12/13 inhibitor
|
ZSQ836 (ZSQ 836) is a potent, selective and orally bioavailable CDK12/CDK13 covalent inhibitor with IC50 of 32 nM (CDK12), covalently interacts with Cys1039 of CDK12. |
| PC-49204 |
SNX631
CDK8/19 inhibitor
|
SNX631 (SNX-631) is a potent, selective inhibitor of CDK8/19 Mediator kinase with IC50 of 10.3 nM in the NF κB-dependent cell-based assays. |
| PC-49131 |
Culmerciclib
CDK4/6 inhibitor
|
TQB3616 (Culmerciclib) is a potent, selective inhibitor of CDK4/6 with IC50 of 0.35 nM and 0.49 nM for CDK4/D1CDK6/D1 respectively, shows remarkable inhibitory effect on hormone receptor-positive breast cancer cells. |
| PC-49130 |
Crozbaciclib
CDK4/6 inhibitor
|
Crozbaciclib is a highly potent, selective, blood-brain barrier (BBB) permeable CDK4/6 inhibitor with IC50 values of 3 nM and 1 nM against CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
| PC-49076 |
CDK inhibitor 24
CDK inhibitor
|
CDK inhibitor 24 is a potent inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 4/20/64 nM for CDK2/9/12, respectively. |
| PC-47100 |
YPN-005
CDK7 inhibitor
|
YPN-005 (YPN005) is a highly potent, selective inhibitor of cyclin-dependent kinase 7 (CDK7) with IC50 of 31 nM, with low inhibition for CDK2 and CDK5. |
| PC-47009 |
Cdk5 inhibitor 25-106
Cdk5/p35 inhibitor
|
Cdk5 inhibitor 25-106 is a potent, brain-penetrant inhibitor of Cdk5/p35 activity with IC50 of 178 nM. |
| PC-38769 |
ERP1.28a
CDC-7 inhibitor
|
ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS. |
| PC-38768 |
ERP1.14a
CDC-7 inhibitor
|
ERP1.14a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 125 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS. |
