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Chemical Structure : LDC4297
CAS No.: 1453834-21-3
Catalog No.: PC-20316Not For Human Use, Lab Use Only.
LDC4297 (LDC044297) is a potent, highly specific CDK7 inhibitor with IC50 of 7.4 nM in ATP competition assays (3.5 mM ATP), weakly inhibits CDK2 (IC50>2 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | Get quote |
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LDC4297 (LDC044297) is a potent, highly specific CDK7 inhibitor with IC50 of 7.4 nM in ATP competition assays (3.5 mM ATP), weakly inhibits CDK2 (IC50>2 uM).
LDC4297 prevents RNA polymerase II (RNAPII) transcription in an inducible-gene setting, reduces in vitro transcription by RNAPII.
LDC4297 causes tumor cell death and cell-type-dependent cell cycle delay in A549 cells and HCT116 cells.
LDC4297 effectively blocks the replication of human cytomegalovirus (HCMV) in primary human fibroblasts with EC50 of 24.5 nM, interferes HCMV-driven inactivation of retinoblastoma protein (Rb), a regulatory step generally considered a hallmark of herpesviral replication.
| M.Wt | 432.53 | |
| Formula | C23H28N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-yloxy)pyrazolo[1,5-a][1,3,5]triazin-4-amine |
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1. Kelso TW, et al. Mol Cell Biol. 2014 Oct 1;34(19):3675-88.
2. Hutterer C, et al. Antimicrob Agents Chemother. 2015 Apr;59(4):2062-71.
3. Ghezzi C, et al. Nat Commun. 2019 Nov 29;10(1):5444.
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