Catalog No.: PC-20316Not For Human Use, Lab Use Only.
LDC4297 (LDC044297) is a potent, highly specific CDK7 inhibitor with IC50 of 7.4 nM in ATP competition assays (3.5 mM ATP), weakly inhibits CDK2 (IC50>2 uM).
LDC4297 (LDC044297) is a potent, highly specific CDK7 inhibitor with IC50 of 7.4 nM in ATP competition assays (3.5 mM ATP), weakly inhibits CDK2 (IC50>2 uM).
LDC4297 prevents RNA polymerase II (RNAPII) transcription in an inducible-gene setting, reduces in vitro transcription by RNAPII.
LDC4297 causes tumor cell death and cell-type-dependent cell cycle delay in A549 cells and HCT116 cells.
LDC4297 effectively blocks the replication of human cytomegalovirus (HCMV) in primary human fibroblasts with EC50 of 24.5 nM, interferes HCMV-driven inactivation of retinoblastoma protein (Rb), a regulatory step generally considered a hallmark of herpesviral replication.
