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Chemical Structure : ISM042-2-048
Catalog No.: PC-49785Not For Human Use, Lab Use Only.
ISM042-2-048 is a potent, selective inhibitor of cyclin-dependent kinase 20 (CDK20, cell cycle-related kinase/CCRK) with IC50 of 33.4 nM (CDK20/CycT1), Kd value of 566 nM.
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ISM042-2-048 is a potent, selective inhibitor of cyclin-dependent kinase 20 (CDK20, cell cycle-related kinase/p42 CCRK) with IC50 of 33.4 nM (CDK20/CycT1), Kd value of 566 nM.
ISM042-2-048 demonstrated selective anti-proliferation activity in an HCC cell line with CDK20 overexpression, Huh7, with an IC50 of 208.7 ± 3.3 nM, compared to a counter screen cell line HEK293 (IC50 = 1706.7 ± 670.0 nM).
ISM042-2-048 is a tool molecule to evaluate biological functions for CDK20.
CDK20, also known as cell cycle-related kinase (CCRK), is overexpressed in many tumor cell lines including tumor samples from patients with different types of cancer, such as colorectal cancer, hepatocellular carcinoma (HCC), lung cancer, and ovarian carcinoma.
| M.Wt | 333.36 | |
| Formula | C17H15N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ren F, et al. Chem Sci. 2023 Jan 10;14(6):1443-1452.
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