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Chemical Structure : PF-07104091
CAS No.: 2460249-19-6
Catalog No.: PC-20283Not For Human Use, Lab Use Only.
PF-07104091 (PF 07104091) is a highly potent CDK2-selective inhibitor with potential for the treatment of cyclinE-amplified cancers.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $248 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $548 | In stock | |
| 25 mg | $858 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-07104091 (PF 07104091) is a highly potent CDK2-selective inhibitor with potential for the treatment of cyclinE-amplified cancers.
PF-07104091 displays 100-fold selectivity against CDK1, 200 to 400-fold selectivity against CDK4 and CDK6, 170-fold selectivity against CDK9, and greater than 500-fold selectivity against GSK3B.
PF-07104091 demonstrated a dose-dependent tumor growth reduction with 86 percent maximal effect in ovarian cancer model and demonstrated single-agent efficacy across multiple ovarian models.
| M.Wt | 404.47 | |
| Formula | C19H28N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1R,3S)-3-(3-(3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-5-yl)cyclopentyl isopropylcarbamate |
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1. Hoffman, R. L., PF-07104091: A CDK2 selective inhibitor of cyclinE amplified cancers. In AACR Annual Meeting 2021, Session DDT02.
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