| Cat. No. |
Product Name |
Information |
| PC-63209 |
Alsteropaullone
CDK/GSK3β inhibitor
|
Alsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM. |
| PC-43098 |
Ro-3306
CDK1 inhibitor
|
Ro-3306 is a potent, selective, ATP-competitive CDK1 inhibitor with Ki of 35 nM against CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D. |
| PC-43037 |
CDKI-73
CDK9 inhibitor
|
Asnuciclib (CDKI-73) is a potent CDK9 inhibitor with Ki of 4 nM, shows cytotoxicity against a broad CLL samples with mean LD50 of 80 nM. |
| PC-42965 |
Kenpaullone
CDK nhibitor
|
Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM). |
| PC-42956 |
LY2857785
CDK9 inhibitor
|
LY2857785 is a potenrt, reversible and ATP-competitive CDK9 inhibitor with IC50 of 11 nM, also inhibits CDK8 (IC50=16 nM) and weakly inhibits CDK7 (IC50=246 nM). |
| PC-42944 |
THZ2
CDK7 inhibitor
|
THZ2, an analogue of THZ1 with improved pharmacokinetic features, is a potent, selective CDK7 inhibitor with IC50 of 13.9 nM, displays a 5-fold improved half-life in vivo compared with THZ1. |
| PC-63139 |
TAK-931
Cdc7 inhibitor
|
TAK-931 (Simurosertib) is a potent, selective, ATP competitive and orally bioavailable inhibitor of Cdc7 with IC50 of <0.3 nM. |
| PC-63127 |
Enitociclib
CDK9 inhibitor
|
Enitociclib ((±)-BAY-1251152) is a potent, highly specific P-TEFb/CDK9 inhibitor with IC50 of 3 nM. displays> 50-fold selectivity against other CDKs. |
| PC-63039 |
Apcin
APC inhibitor
|
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
| PC-62864 |
CAN-508
CDK9 inhibitor
|
CAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM). |
| PC-62682 |
Ibulocydine
CDK7/9 inhibitor
|
Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively. |
| PC-62680 |
NSC 625987
CDK4 inhibitor
|
NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E). |
