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Chemical Structure : FMF-04-159-2
CAS No.: 2364489-81-4
Catalog No.: PC-36163Not For Human Use, Lab Use Only.
FMF-04-159-2 is a potent, selective, covalent CDK14 inhibitor (IC50=86 nM) with pan-TAIRE family specificity (CDKs 14-18).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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FMF-04-159-2 is a potent, selective, covalent CDK14 inhibitor (IC50=86 nM) with pan-TAIRE family specificity (CDKs 14-18).
FMF-04-159-2 potently inhibited the TAIRE kinases CDK14, CDK16, CDK17, and CDK18.
CDK14 was potently engaged by FMF-04-159-2 (IC50=39.6 nM), and this engagement was sustained after a 2-h, compound washout (IC50=56.3 nM), indicates irreversible binding.
FMF-04-159-2 is a valuable tool for study of CDK14 kinase function.
| M.Wt | 683.002 | |
| Formula | C28H30Cl3N7O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-N-(1-((3-(4-(dimethylamino)but-2-enamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide |
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1. Ferguson FM, et al. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4.
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