Catalog No.: PC-38299Not For Human Use, Lab Use Only.
(R)-CR8 is a potent CDK1/2/5/7/9 inhibitor, inhibits CDK1/cyclin B (IC50, 90 nM), CDK2/cyclin A (72 nM), CDK2/cyclin E (41 nM), CDK5/p25 ( 110 nM), CDK7/cyclin H (1.1 uM), CDK9/cyclin T (0.18 uM) and CK1δ/ε (0.4 uM).
(R)-CR8 (CR8) is a potent CDK1/2/5/7/9 inhibitor, inhibits CDK1/cyclin B (IC50, 90 nM), CDK2/cyclin A (72 nM), CDK2/cyclin E (41 nM), CDK5/p25 ( 110 nM), CDK7/cyclin H (1.1 uM), CDK9/cyclin T (0.18 uM) and CK1δ/ε (0.4 uM).
(R)-CR8 induces apoptosis and has neuroprotective effect.
CR8 binds CDK12-cyclin K and recruits the DDB1–CUL4–RBX1 E3 ligase core to ubiquitinate cyclin K
(R)-CR8 also acts as a molecular glue degrader that depletes cyclin K.
