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Chemical Structure : (R)-CR8
CAS No.: 294646-77-8
Catalog No.: PC-38299Not For Human Use, Lab Use Only.
(R)-CR8 is a potent CDK1/2/5/7/9 inhibitor, inhibits CDK1/cyclin B (IC50, 90 nM), CDK2/cyclin A (72 nM), CDK2/cyclin E (41 nM), CDK5/p25 ( 110 nM), CDK7/cyclin H (1.1 uM), CDK9/cyclin T (0.18 uM) and CK1δ/ε (0.4 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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(R)-CR8 (CR8) is a potent CDK1/2/5/7/9 inhibitor, inhibits CDK1/cyclin B (IC50, 90 nM), CDK2/cyclin A (72 nM), CDK2/cyclin E (41 nM), CDK5/p25 ( 110 nM), CDK7/cyclin H (1.1 uM), CDK9/cyclin T (0.18 uM) and CK1δ/ε (0.4 uM).
(R)-CR8 induces apoptosis and has neuroprotective effect.
CR8 binds CDK12-cyclin K and recruits the DDB1–CUL4–RBX1 E3 ligase core to ubiquitinate cyclin K
(R)-CR8 also acts as a molecular glue degrader that depletes cyclin K.
| M.Wt | 431.544 | |
| Formula | C24H29N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-butanol-1 |
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1. Słabicki M, et al. Nature. 2020 Sep;585(7824):293-297.
2. Huang BY, et al. CNS Neurosci Ther. 2019 May;25(5):612-620.
3. Husson H, et al. Hum Mol Genet. 2016 Jun 1;25(11):2245-2255.
4. Delehouzé C, et al. Oncogene. 2014 Dec 11;33(50):5675-87.
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