LY3405105 | CDK7 inhibitor | Probechem Biochemicals

Chemical Structure : LY3405105

LY3405105 (LY-3405105)

Catalog No.: PC-72467Not For Human Use, Lab Use Only.

LY3405105 (LY-3405105) is a potent, selective, orally active CDK7 inhibitor with an IC50 of 92.8 nM, shows potential antineoplastic activity.

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Biological Activity

LY3405105 (LY-3405105) is a potent, selective, covalent and orally active CDK7 inhibitor with an IC50 of 92.8 nM, shows potential antineoplastic activity.

Physicochemical Properties

M.Wt	497.644
Formula	C26H39N7O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester

References

1. Georgina P Sava, et al. Cancer Metastasis Rev. 2020 Sep;39(3):805-823.

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LY3405105 (LY-3405105)

Biological Activity

Physicochemical Properties

References

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