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Chemical Structure : SY-5102
Catalog No.: PC-72466Not For Human Use, Lab Use Only.
SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H).
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SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H).
SY-5102 (SY5102) displays highly selectivity against CDK2, CDK9, and CDK12 (all IC50>75 nM).
SY-5102 potently inhibits HCC70 cell proliferation with EC50 of 9 nM.
SY-5102 showed dose-dependent tumor growth inhibition including tumor regression at 4 mg/kg po (dosed twice daily) in an HCC70 cell line derived xenograft mouse model.
| M.Wt | 457.45 | |
| Formula | C22H22F3N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jason J Marineau, et al. J Med Chem. 2022 Jan 27;65(2):1458-1480.
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