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Chemical Structure : KB-0742
CAS No.: 2416873-83-9
Catalog No.: PC-38278Not For Human Use, Lab Use Only.
KB-0742 (KB0742) is a potent, orally bioavailable, selective CDK9 inhibitor with IC50 of 6 nM (CDK9/cyclin T1 inhibition).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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KB-0742 (KB0742) is a potent, orally bioavailable, selective CDK9 inhibitor with IC50 of 6 nM (CDK9/cyclin T1 inhibition).
KB-0742 displays >60-fold selectivity over CDK2/12/13, and >200-fold over other CDKs.
KB-0742 rapidly downregulates nascent transcription, preferentially depleting short half-life transcripts and AR-driven oncogenic programs.
Oral administration of KB-0742 significantly reduced tumor growth in CRPC models.
| M.Wt | 287.411 | |
| Formula | C16H25N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1S,3S)-N1-(5-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine |
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1. André Richters, et al. Cell Chem Biol. 2021 Feb 18;28(2):134-147.e14.
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