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KB-0742

Chemical Structure : KB-0742

CAS No.: 2416873-83-9

KB-0742 (KB0742)

Catalog No.: PC-38278Not For Human Use, Lab Use Only.

KB-0742 (KB0742) is a potent, orally bioavailable, selective CDK9 inhibitor with IC50 of 6 nM (CDK9/cyclin T1 inhibition).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KB-0742 (KB0742) is a potent, orally bioavailable, selective CDK9 inhibitor with IC50 of 6 nM (CDK9/cyclin T1 inhibition).
KB-0742 displays >60-fold selectivity over CDK2/12/13, and >200-fold over other CDKs.
KB-0742 rapidly downregulates nascent transcription, preferentially depleting short half-life transcripts and AR-driven oncogenic programs.
Oral administration of KB-0742 significantly reduced tumor growth in CRPC models.

Physicochemical Properties

M.Wt 287.411
Formula C16H25N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1S,3S)-N1-(5-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine

References

1. André Richters, et al. Cell Chem Biol. 2021 Feb 18;28(2):134-147.e14.

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