BRD6688 is a potent, kinetically selective HDAC2 inhibitor with IC50 of 21/100 nM for HDAC1/2, >115-fold selectivity versus HDAC3.
BRD6688 produced significant increases in AcH4K12 and AcH3K9 in mouse forebrain primary neuronal cultures.
BRD6688 rescued the memory defects associated with p25 induced neurodegeneration in CK-p25 induced neurodegenerative model.
