| Cat. No. |
Product Name |
Information |
| PC-61143 |
AZD 5597
CDK1/2 inhibitor
|
AZD 5597 is a highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2. |
| PC-61136 |
CDK2 inhibitor 73
CDK2 inhibitor
|
CDK2 inhibitor 73 (CDK2-IN-4) is a potent, selective CDK2 inhibitor with IC50 of 44 nM for CDK2/cyclin A, displays 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM). |
| PC-61031 |
Voruciclib
CDK9 inhibitor
|
Voruciclib (P1446A-05) is a potent, selective and orally bioavailable CDK9 inhibitor with Ki of 0.63 nM and 1.68 nM for CDK9/cyclinT2 and CDK9/cyclinT1, respectively. |
| PC-61020 |
Cdc7 inhibitor 7c
Cdc7 inhibitor
|
Cdc7 inhibitor 7c (Cdc7-IN-7c) is a highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively. |
| PC-60961 |
YKL-1-116
CDK7 inhibitor
|
YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs. |
| PC-60894 |
Cortistatin A
CDK8/19 inhibitor
|
Cortistatin A is a potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19. |
| PC-60893 |
BRD6989
CDK8 inhibitor
|
BRD6989 is a potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex. |
| PC-60582 |
(R)-DRF053 dihydrochloride
CK1/CDK inhibitor
|
(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively. |
| PC-60539 |
BAY-958
CDK9 inhibitor
|
BAY-958 (BAY958, LDC526) is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1. |
| PC-60537 |
Atuveciclib
CDK9 inhibitor
|
Atuveciclib (BAY-1143572) is a potent, highly selective, orally bioavailable CDK9/P-TEFb inhibitor with IC50 of 6 nM for CDK9/CyclinT1. |
| PC-60492 |
CDK12 inhibitor E9 racemate
CDK12 inhibitor
|
CDK12 inhibitor E9 racemate is a clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux. |
| PC-60491 |
CDK12 inhibitor E9 R-isomer
CDK12 inhibitor
|
CDK12 inhibitor E9 R-isomer is a clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux. |
