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Cat. No. Product Name Information
PC-20283

PF-07104091

CDK2 inhibitor

PF-07104091 (PF 07104091) is a highly potent CDK2-selective inhibitor with potential for the treatment of cyclinE-amplified cancers.
PC-49792

CDKL5/GSK3 inhibitor 2

CDKL5 inhibitor

CDKL5/GSK3 inhibitor 2 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively.
PC-49787

BMS-357075

pan CDK inhibitor

BMS-357075 is a potent pan inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 18, 3 and 26 nM for CDK1, CDK2, and CDK4, respectively, also inhibits CDK20 with Kd of 56 nM.
PC-49786

MER-128

CDK20 inhibitor

MER-128 is a potent, selective CDK20 inhibitor with IC50 of 2 nM.
PC-49698

EF-4-177

CDK2 inhibitor

EF-4-177 is a potent, selective, allosteric and orally active CDK2 inhibitor with ITC KD of 7.4 nM.
EF-4-177 binds CDK2 in a manner that is negatively cooperative with cyclin binding.
PC-49575

CDK4/6-IN-6

CDK4/6 inhibitor

CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
PC-49444

MK256

CDK8 inhibitor

MK256 (MK-256) is a potent, selective CDK8 inhibitor with IC50 of 2.5 nM and 3.3 nM against CDK8/cyclin C and CDK19/cyclin C, respectively.
PC-49295

BML-259

CDK5 inhibitor

BML-259 (BML259) is a potent, specific Cdk5/p25 and Cdk2 inhibitor with IC50 of 64 and 98 nM, respectively.
PC-47009

Cdk5 inhibitor 25-106

Cdk5/p35 inhibitor

Cdk5 inhibitor 25-106 is a potent, brain-penetrant inhibitor of Cdk5/p35 activity with IC50 of 178 nM.
PC-38769

ERP1.28a

CDC-7 inhibitor

ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS.
PC-38768

ERP1.14a

CDC-7 inhibitor

ERP1.14a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 125 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS.
PC-38750

ZNL-05-044

CDK11 inhibitor

ZNL-05-044 is a potent, selective CDK11 inhibitor with Kd of 69 nM (CDK11A), shows significantly kinome-wide selectivity. ZNL-05-044 treatment leads to G2/M cell cycle arrest, impacts CDK11-dependent mRNA splicing in cells.

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