Cat. No. |
Product Name |
Information |
PC-20283 |
PF-07104091
CDK2 inhibitor
|
PF-07104091 (PF 07104091) is a highly potent CDK2-selective inhibitor with potential for the treatment of cyclinE-amplified cancers. |
PC-49792 |
CDKL5/GSK3 inhibitor 2
CDKL5 inhibitor
|
CDKL5/GSK3 inhibitor 2 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively. |
PC-49787 |
BMS-357075
pan CDK inhibitor
|
BMS-357075 is a potent pan inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 18, 3 and 26 nM for CDK1, CDK2, and CDK4, respectively, also inhibits CDK20 with Kd of 56 nM. |
PC-49786 |
MER-128
CDK20 inhibitor
|
MER-128 is a potent, selective CDK20 inhibitor with IC50 of 2 nM. |
PC-49698 |
EF-4-177
CDK2 inhibitor
|
EF-4-177 is a potent, selective, allosteric and orally active CDK2 inhibitor with ITC KD of 7.4 nM. EF-4-177 binds CDK2 in a manner that is negatively cooperative with cyclin binding. |
PC-49575 |
CDK4/6-IN-6
CDK4/6 inhibitor
|
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. |
PC-49444 |
MK256
CDK8 inhibitor
|
MK256 (MK-256) is a potent, selective CDK8 inhibitor with IC50 of 2.5 nM and 3.3 nM against CDK8/cyclin C and CDK19/cyclin C, respectively. |
PC-49295 |
BML-259
CDK5 inhibitor
|
BML-259 (BML259) is a potent, specific Cdk5/p25 and Cdk2 inhibitor with IC50 of 64 and 98 nM, respectively. |
PC-47009 |
Cdk5 inhibitor 25-106
Cdk5/p35 inhibitor
|
Cdk5 inhibitor 25-106 is a potent, brain-penetrant inhibitor of Cdk5/p35 activity with IC50 of 178 nM. |
PC-38769 |
ERP1.28a
CDC-7 inhibitor
|
ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS. |
PC-38768 |
ERP1.14a
CDC-7 inhibitor
|
ERP1.14a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 125 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS. |
PC-38750 |
ZNL-05-044
CDK11 inhibitor
|
ZNL-05-044 is a potent, selective CDK11 inhibitor with Kd of 69 nM (CDK11A), shows significantly kinome-wide selectivity. ZNL-05-044 treatment leads to G2/M cell cycle arrest, impacts CDK11-dependent mRNA splicing in cells. |