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Chemical Structure : CCT-251921
CAS No.: 1607837-31-9
Catalog No.: PC-61146Not For Human Use, Lab Use Only.
CCT-251921 (CCT251921) is a potent, selective, and orally bioavailable inhibitor of CDK8 and CDK19 with IC50of 2.3 nM and 2.6 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CCT-251921 (CCT251921) is a potent, selective, and orally bioavailable inhibitor of CDK8 and CDK19 with IC50of 2.3 nM and 2.6 nM respectively.
CCT-251921 reduces STAT1 Ser727 phosphorylation, inhibits tunor growth of APC-mutant SW620 human colorectal carcinoma xenograft mode, has pharmacokinetic, and physicochemical properties.
| M.Wt | 410.906 | |
| Formula | C21H23ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-(2-Amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one |
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1. Mallinger A, et al. J Med Chem. 2016 Feb 11;59(3):1078-101.
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