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Chemical Structure : AZ5576
CAS No.: 2751721-40-9
Catalog No.: PC-61405Not For Human Use, Lab Use Only.
AZ5576 (AZ-5576) is a potent, highly selective, and orally bioavailable inhibitor of CDK9 with IC50 of < 5 nM, decreases phosphorylation of Ser2-RNAPII in cells with an IC50 of 96 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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AZ5576 (AZ-5576) is a potent, highly selective, and orally bioavailable inhibitor of CDK9 with IC50 of < 5 nM, decreases phosphorylation of Ser2-RNAPII in cells with an IC50 of 96 nM.
AZ5576 causes a rapid dose- and time-dependent decrease in pSer2-RNAPII with concomitant loss of Mcl1 and Myc mRNA and protein, resulting in the cleavage and activation of caspase 3 and loss of cell viability.
| M.Wt | 385.43 | |
| Formula | C21H24FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1S,3R)-3-Acetamido-N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexane-1-carboxamide |
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1. Taylor Hashiguchi, et al. Mol Cancer Ther. 2019 Sep;18(9):1520-1532.
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