Catalog No.: PC-61658Not For Human Use, Lab Use Only.
SEL120-34A is an ATP-competitive, selective, orally active CDK8/19 inhibitor that inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50 of 4.4 nM and 10.4 nM, respectively.
SEL120-34A is an ATP-competitive, selective, orally active CDK8/19 inhibitor that inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50 of 4.4 nM and 10.4 nM, respectively.
SEL120-34A shows no significant inhibition on other members of the CDK family (200-fold over CDK9).
SEL120-34A inhibits phosphorylation of STAT1 S727 and STAT5 S726 in cancer cells, inhibits IFN- responsive genes expression in vitro.
SEL120-34A exhibits complete inhibitions of STAT1 S727 and STAT5 S726 in Colo-205 CRC xenograft tissues in mice (60mg/kg).
