Catalog No.: PC-61279Not For Human Use, Lab Use Only.
Riviciclib (P276-00 hydrochloride) is a potent CDK inhibitor with IC50 of 79 nM, 63 nM and 20 nM for Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, respectively.
Riviciclib (P276-00 hydrochloride) is a potent CDK inhibitor with IC50 of 79 nM, 63 nM and 20 nM for Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, respectively.
Riviciclib (P276-00 hydrochloride) weakly inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk6/cyclin D3 and Cdk7/cyclin H with IC50 of 0.2-3 uM.
Riviciclib (P276-00 hydrochloride) shows potent antiproliferative effects against various human cancer cell lines (IC50=200-800 nM).
Riviciclib (P276-00 hydrochloride) induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models.
