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Chemical Structure : AZD 5597
CAS No.: 924641-59-8
Catalog No.: PC-61143Not For Human Use, Lab Use Only.
AZD 5597 is a highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $258 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AZD 5597 is a highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2.
AZD 5597 exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM, demonstrates anticancer activity in SW620 tumour xenograft, possesses suitable physiochemical and pharmacokinetic profiles for intravenous (i.v.) dosing.
| M.Wt | 437.513 | |
| Formula | C23H28FN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-(4-((5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone |
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1. Jones CD, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6369-73.
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