Catalog No.: PC-61916Not For Human Use, Lab Use Only.
ICEC0942 (Samuraciclib, CT7001) is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM).
ICEC0942 (Samuraciclib, CT7001) is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM).
ICEC0942 displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2, CDK5 and CDK9.
ICEC0942 demonstrates sensitivity against a wide range of cancer types with GI50 values ranging between 0.2-0.3 uM.
ICEC0942 shows substantial anti-tumor effects in xenografts of both breast and colorectal cancers, also exhibits complete growth arrest of ER-positive tumor xenografts combined with tamoxifen.
