| Cat. No. |
Product Name |
Information |
| PC-25121 |
BEBT-209
CDK4 inhibitor
|
BEBT-209 is a potent, selective and orally active CDK4 inhibitor, 6-fold selective over CDK6. |
| PC-24695 |
FCN-437c
CDK4/6 inhibitor
|
FCN-437c (FCN-437) is a potent, selective and orally active inhibitor of CDK4/6, shows selective inhibitory activities against CDK4/6 over other CDKs. |
| PC-24595 |
MRT-9643
CDK2 degrader
|
MRT-9643 (MRT9643) is a potent, selective and orally active CDK2-directed molecular glue degrader, induces CDK2-dependent cancer cell growth inhibition. |
| PC-24494 |
Y041-2712
CDK8 inhibitor
|
Y041-2712 is a potent, selective CDK8 inhibitor with IC50 value of 398.8 nM, inhibits TGF-β/Smad signaling pathway and the expression of EMT proteins. |
| PC-24482 |
LA-CB1
CDK4/6 degrader
|
LA-CB1 is a novel Abemaciclib derivative that induces CDK4/6 degradation through the ubiquitin-proteasome pathway, exerts robust anti-proliferative effects across a wide spectrum of cancer cell lines (A498 cell, IC50=0.21 uM). |
| PC-24198 |
Zeltociclib
CDK7 inhibitor
|
Zeltociclib is a potent, specific CDK7 inhibitor. |
| PC-24041 |
F059-1017
CDK8 inhibitor
|
F059-1017 is a potent, selective CDK8 inhibitor with IC50 of 558.1 nM, reduces phosphorylation and expression of signaling mediators associated with inflammation. |
| PC-23981 |
Arcyriaflavin A
CDK4 inhibitor
|
Arcyriaflavin A is a potent inhibitor of the cyclin D1/CDK4 complex with IC50 of 140 nM, also inhibits CaMKII with IC50 of 25 nM, suppresses tumor growth, migration, and invasion of metastatic melanoma cells. |
| PC-23770 |
E966-0530-45418
CDK8 inhibitor
|
E966-0530-45418 is a potent, selective inhibitor of CDK8 with IC50 of 129 nM, shows slightly weaker activity against CDK19 and does not inhibit other CDKs. |
| PC-23046 |
Myrtleciclib
CDK4/6/9 inhibitor
|
Myrtleciclib (VS2 370) is a potent, selective CDK4/6/9 inhibitor. |
| PC-23020 |
YK-2168 hydrochloride
CDK9 inhibitor
|
YK-2168 hydrochloride is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2. |
| PC-22926 |
TMX-3013
CDK inhibitor
|
TMX-3013 is a potent, multi-CDK inhibitor with IC50 of 0.9/<0.5/0.5/24.5/15.6 nM for CDK1/2/5/4/6 respectively. |
