BRD6866

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Chemical Structure : BRD6866

Catalog No.: PC-25401Not For Human Use, Lab Use Only.

BRD6866 is a small molecule inhibitor of TFE3 transcription factor fusion activity with IC50 of 342 nM, shows dose-dependent chromatin trapping of TFE3, potent pan-CDK inhibitor across all families of CDKs, including both cell-cycle and transcriptional CDK9, suppresses tRCC cell growth.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	375.47
Formula	C16H17N5O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N,4-dimethyl-5-(2-((3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)thiazol-2-amine

References

1. Dharma R Thapa, et al. bioRxiv [Preprint]. 2025 Aug 30:2025.08.25.672235.

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BRD6866

Biological Activity

Physicochemical Properties

References

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