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CIRc-028

Chemical Structure : CIRc-028

CAS No.: 3036232-03-5

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CIRc-028 (CIRc028)

Catalog No.: PC-25359Not For Human Use, Lab Use Only.

CIRc-028 is a potent, in vivo-active, orally bioavailable dual cyclin A/B RxL inhibitor, inhibits cyclin A/B-RxL interactions and induces apoptosis in cancer cells with high E2F activity, induced spindle assembly checkpoint (SAC) activation and apoptosis in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CIRc-028 is a potent, in vivo-active, orally bioavailable dual cyclin A/B RxL inhibitor, inhibits cyclin A/B-RxL interactions and induces apoptosis in cancer cells with high E2F activity, induced spindle assembly checkpoint (SAC) activation and apoptosis in vivo.

Physicochemical Properties

M.Wt 976.93
Formula C45H63Cl2F4N7O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,4R)-N-((S)-3-cyclobutyl-1-(((6S,9S,12S)-6-(2,5-dichlorobenzyl)-9-isobutyl-5,8,11,18-tetraoxo-7-propyl-4,7,10,17-tetraazaspiro[2.15]octadecan-12-yl)(methyl)amino)-1-oxopropan-2-yl)-4-fluoro-1-((R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)pyrrolidine-2-carboxamide

References

1. Singh S, et al. Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09433-w.

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