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Chemical Structure : Roscovitine
CAS No.: 186692-46-6
Catalog No.: PC-45792Not For Human Use, Lab Use Only.
Roscovitine ((R)-Roscovitine, Seliciclib, CYC202) is a potent and selective CDK inhibitor with IC50 of 0.2 uM, 0.65 uM, and 0.7 uM for CDK5, Cdc2, and CDK2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $68 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $178 | In stock | |
| 100 mg | $278 | In stock | |
| 250 mg | Get quote |
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Roscovitine ((R)-Roscovitine, Seliciclib, CYC202) is a potent and selective CDK inhibitor with IC50 of 0.2 uM, 0.65 uM, and 0.7 uM for CDK5, Cdc2, and CDK2, respectively.
Roscovitine weakly inhibits ERK1 and ERK2 (IC50=34 uM and 14 uM), poorly inhibits CDK4/cyclin D1 and CDK6/cyclin D2 (IC50>100 uM).
Roscovitine suppresses the proliferation of mammalian cell lines with an average IC50 of 16 uM.
Roscovitine significantly inhibits growth of The Ewing's sarcoma family of tumors (ESFT) xenografts.
| M.Wt | 354.4493 | |
| Formula | C19H26N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)- |
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1. Meijer L, et al. Eur J Biochem. 1997 Jan 15;243(1-2):527-36.
2. Tirado OM, et al. Cancer Res, 2005, 65(20), 9320-9327.
3. Mgbonyebi OP, et al. Cancer Res. 1999 Apr 15;59(8):1903-10.
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