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Chemical Structure : GW-8510
CAS No.: 222036-17-1
Catalog No.: PC-70170Not For Human Use, Lab Use Only.
GW-8510 (GW8510) is a potent, selective inhibitor of CDK2 with IC50 of 10 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $558 | In stock | |
| 100 mg | Get quote |
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GW-8510 (GW8510) is a potent, selective inhibitor of CDK2 with IC50 of 10 nM.
GW-8510 displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays.
GW-8510 only inhibits CDK5 on cultured neurons; downregulates the expression of XIAP and no detectable effect on the expression of Bax, Bak, or Bcl2.
GW-8510 also demonstrates neuroprotective ability in MN9D cells in the presence of 1-methyl-4-phenylpyridium (MPP(+)).
| M.Wt | 449.51 | |
| Formula | C21H15N5O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinylbenzenesulfonamide |
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1. Johnson K, et al. J Neurochem. 2005 May;93(3):538-48.
2. Davis ST, et al. Science. 2001 Jan 5;291(5501):134-7. Retraction. [Science. 2002]
3. Wimalasena NK, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):857-63.
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