GW-8510 (GW8510) is a potent, selective inhibitor of CDK2 with IC50 of 10 nM.
GW-8510 displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays.
GW-8510 only inhibits CDK5 on cultured neurons; downregulates the expression of XIAP and no detectable effect on the expression of Bax, Bak, or Bcl2.
GW-8510 also demonstrates neuroprotective ability in MN9D cells in the presence of 1-methyl-4-phenylpyridium (MPP(+)).
