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Chemical Structure : VMY-1-103
Catalog No.: PC-70177Not For Human Use, Lab Use Only.
VMY-1-103 is a dansylated analog of purvalanol B, and a CDK inhibitor that inhibits cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B.
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VMY-1-103 is a dansylated analog of purvalanol B, and a CDK inhibitor that inhibits cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B.
VMY-1-103 increases the sub G(1) fraction of apoptotic cells, induces PARP and caspase-3 cleavage and increases the levels of the death receptors DR4 and DR5, Bax and Bad.
| M.Wt | 708.27 | |
| Formula | C34H42ClN9O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ringer L, et al. Cancer Biol Ther. 2011 Nov 1;12(9):818-26.
2. Sirajuddin P, et al. Cell Cycle. 2012 Oct 15;11(20):3801-9.
3. Waye S, et al. Aging (Albany NY). 2015 Oct;7(10):854-68.
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