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Chemical Structure : Trilaciclib
CAS No.: 1374743-00-6
Catalog No.: PC-60395Not For Human Use, Lab Use Only.
Trilaciclib (G1T28) is a novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 4 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively.
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|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $288 | In stock | |
| 100 mg | $698 | In stock | |
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| 1 g | Get quote |
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Trilaciclib (G1T28) is a novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 4 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively.
Trilaciclib (G1T28) displays >30-fold selectivity for CDK4/cyclin D1 over CDK2/cyclin A, CDK2/cyclin E, CDK5/p25, CDK5/p35, and CDK7/cyclin H/Mat1, 50-fold over CDK9/cyclin T.
Trilaciclib (G1T28) reversibly pauses the cell cycle in the G1 phase in CDK4/6-dependent cell lines, protects CDK4/6-dependent cells from chemotherapy-induced damage in vitro.
Trilaciclib (G1T28) induces a reversible cell-cycle arrest in murine and canine HSPCs; attenuates chemotherapy-induced myelosuppression in vivo.
| M.Wt | 446.55 | |
| Formula | C24H30N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one |
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1. Bisi JE, et al. Mol Cancer Ther. 2016 May;15(5):783-93.
2. He S, et al. Sci Transl Med. 2017 Apr 26;9(387). pii: eaal3986.
3. Stice JP, et al. Mol Cancer Res. 2017 Jun;15(6):660-669.
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