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Chemical Structure : (R)-DRF053 dihydrochloride
Catalog No.: PC-60582Not For Human Use, Lab Use Only.
(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively.
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(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively.
(R)-DRF053 exhibits antiproliferative activity against human neuroblastoma SH-SY5Y cells with EC50 of 17.2 uM, prevents the CK1-dependent production of amyloid-beta in a cell model.
(R)-DRF053 specifically increases the number of duct-derived β-cells without affecting their proliferation.
| M.Wt | 490.433 | |
| Formula | C23H29Cl2N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Oumata N, et al. J Med Chem. 2008 Sep 11;51(17):5229-42.
2. Zelenak C, et al. Cell Physiol Biochem. 2012;29(1-2):171-80.
3. Liu KC, et al. Diabetes. 2018 Jan;67(1):58-70.
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