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Chemical Structure : NCGC00131308
Catalog No.: PC-20691Not For Human Use, Lab Use Only.
NCGC00131308 is a small molecule inhibitor that effectively disrupts IQGAP1-Cdc42 interaction in breast cancer cells, shows EC50 of 4.47 uM in biochemical HTRF assays.
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NCGC00131308 is a small molecule inhibitor that effectively disrupts IQGAP1-Cdc42 interaction in breast cancer cells, shows EC50 of 4.47 uM in biochemical HTRF assays.
NCGC00131308 exhibits a dose-dependent inhibitory effect on proliferation of MCF7 and MDA-MB-231 cells.
NCGC00131308 binds directly to Cdc42 with Kd value of 28.12 uM.
NCGC00131308 reduces the amount of active Cdc42 induced by EGF in MDA-MB-231 cells, thereby reducing filopodia formation induced by EGF, a phenotype that affects migration of cancer cells.
| M.Wt | 422.39 | |
| Formula | C18H24BrN5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sayedyahossein S, et al. Sci Rep. 2022 Oct 17;12(1):17372.
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