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JH-VIII-49

Chemical Structure : JH-VIII-49

CAS No.: 2209084-73-9

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JH-VIII-49

Catalog No.: PC-63464Not For Human Use, Lab Use Only.

JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM).
JH-VIII-49 displays excellent selectivity against a panel of 468 kinases at a concentration of 10 uM, only 4 has >90% inhibition.
JH-VIII-49 induces a dose-dependent inhibition of S727-STAT1 phosphorylation in HepG2 cells (at 5 uM).

Physicochemical Properties

M.Wt 428.664
Formula C30H40N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,8S,10R,13S,14S,17S)-17-(isoquinolin-7-yl)-N,N,10,13-tetramethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-amine

References

1. John M. Hatcher, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00011

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