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Chemical Structure : Alsteropaullone
Catalog No.: PC-63209Not For Human Use, Lab Use Only.
Alsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM.
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Alsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM; exhibits specific antitumor activity against Group 3 medulloblastomas, causes inhibition of cell cycle-related genes, and down-regulation of MYC; inhibits the cytosolic degradation of β-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, reduces tau phosphorylation.
| M.Wt | 293.3 | |
| Formula | C16H11N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Soni DV, et al. Cell Cycle. 2004 Mar;3(3):349-57.
2. Lahusen T, et al. Mol Carcinog. 2003 Apr;36(4):183-94.
3. Schultz C, et al. J Med Chem. 1999 Jul 29;42(15):2909-19.
4. Faria CC, et al. Oncotarget. 2015 Aug 28;6(25):21718-29.
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